ENCIRCLE: 1-Year Outcomes of Transcatheter Mitral Valve Replacement (TMVR) With the SAPIEN M3 System for Patients Unsuitable for Surgery

Mitral regurgitation remains a challenge to treat in patients for whom transcatheter repair is not feasible. The one-year data of transcatheter mitral valve replacement (TMVR) outcomes from the ENCIRCLE trial, which uses the Sapien M3 system, represent a meaningful step forward in the treatment of mitral regurgitation in patients who are not candidates for surgery or transcatheter repair.

The NOBLE Left Main Revascularization Study

The optimal treatment method (PCI versus coronary artery bypass graft surgery) to obtain long-term success for obstructive left main disease remains controversial. The NOBLE trials examine 10-year mortality outcomes with a strategy of percutaneous coronary angioplasty with drug-eluting stents versus coronary artery bypass graft surgery in the treatment of unprotected left main stenosis.

PARTNER 3: 7-Year Clinical and Echocardiographic Outcomes of TAVR vs. SAVR

There has been a growing trend toward performing PCI in an ambulatory setting, with yet unanswered questions about patient characteristics, volume trends, procedure types, and outcomes. This publication sheds light on those characteristics, trends, and outcomes by comparing patients undergoing ambulatory PCI with those in an outpatient hospital setting.

SELUTION4ISR: Randomized Trial of a Sirolimus Eluting Balloon vs. Repeat Drug-Eluting Stenting or Balloon Angioplasty for Coronary In-stent Restenosis

The SELUTION4ISR trial is a prospective, multicenter, single-blinded, randomized, controlled trial to show that a Sirolimus-eluting balloon approach to in-stent restenosis can achieve non-inferiority to standard of care without the addition of another stent layer.

SELUTION DeNovo: PCI With a Sirolimus-Eluting Balloon and Provisional Stenting Shows Comparable Outcomes to Routine DES Implantation for Treatment of De Novo Coronary Lesions

Drug-eluting stents are the dominant strategy for PCI across the world. Strategies to reduce metallic stent implants have generated recent interest in order to reduce adverse event rates. This trial compared the SELUTION SLR drug-eluting balloon to routine drug-eluting stent in the treatment of de novo coronary artery disease.

STORM PE: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation vs. Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism

Despite 12 years of endovascular therapy for treatment of pulmonary embolism and the presence of seven FDA-approved devices on the market, there is little randomized controlled trial data to support an endovascular approach over anticoagulation (AC) alone. STORM PE randomized catheter-assisted vacuum thrombectomy with AC versus AC alone, with a primary endpoint of the change in RV/LV ratio at 48 hours.

VICTORY: Intravascular Lithotripsy vs. Super-High-Pressure PTCA in Calcified and Refractory Coronary Lesions

Calcified coronary lesions are increasingly encountered during PCI and are associated with worse major adverse cardiovascular outcomes. Yet, randomized controlled data comparing different strategies is limited. VICTORY compares the efficacy and safety of super high-pressure OPN-noncompliant balloon and intravascular lithotripsy. Stent expansion was assessed by optical coherence tomography.